After seven rounds of Aviva Premiership Rugby Sale Sharks are still waiting for their first victory of the season but their has been a shake up in the camp.
Director of Rugby Brian Redpath has effectively been demoted to Head coach and CEO Steve Diamond has taken charge of the team.
While the Sharks are still winless they at least doubled their tally of league points with their losing bonus point at Worcester last Friday.
London Irish lost with the last play of the game against Premiership champions Harlequins at Madejski Stadium on Sunday so they will give Sale a stiff test.
The Exiles' most recent two away wins in the Premiership have both come at Sixways, prior to that it was at Northampton on 17 September 2011.
The two sides each won their respective home game when they met last season, whilst Sale are going for successive home wins over London Irish for the first time since 1999.
Marland Yarde has recovered from injury and returns to the London Irish starting line-up while Sailosi Tagicakibau moves into the centres in place of Jonathan Joseph and Scott Lawson starts at hooker.
Darren Allinson starts his first match of the season at scrum half and will form a combination with Ian Humphreys.
George Skivington is named as a replacement after recovering from injury.
London Irish Director of Rugby Brian Smith said: "Friday evening will be a big test of how far we have come this season. "
"We played some great rugby last weekend and were disappointed not to see it through. We need to make amends tomorrow night. "
"We face a difficult challenge; Sale are a good side with some great players so it will be a tough ask but one we are looking forward to."
Sale have made a number of changes as Mark Cueto changes sides on the wing with .Cameron Shepherd starting at 11 and Tom Brady dropping to the bench.
Match : Sale Sharks v London Irish
Date : Friday 2nd November
Venue : Salford City Stadium
Kick Off : 8pm
Live on: N/A
Referee: Sean Davey (109th Premiership game)
Assistant Referees: Andrew Watson, Alan Hughes
15.Nick Macleod, 14.Mark Cueto, 13.Johnny Leota, 12.Sam Tuitupou, 11.Cameron Shepherd, 10.Danny Cipriani, 9.Cillian Willis, 1.Ross Harrison, 2.Tommy Taylor, 3.Tony Buckley, 4.Richie Gray, 5. Fraser McKenzie, 6.Richie Vernon, 7.David Seymour (capt.), 8.Andy Powell
Replacements: 16.Joe Ward, 17.Eifion Lewis-Roberts, 18.Vadim Cobilas, 19.Kearnan Myall, 20.Mark Easter, 21.Dwayne Peel, 22.Rob Miller, 23.Tom Brady
London Irish :
15. Anthony Watson; 14. Topsy Ojo; 13. Guy Armitage; 12. Sailosi Tagicakibau; 11. Marland Yarde; 10. Ian Humphreys; 9. Darren Allinson; 1. Max Lahiff; 2. Scott Lawson; 3. Halani Aulika; 4. Bryn Evans; 5. Matt Garvey; 6. Declan Danaher (Captain); 7. Jamie Gibson; 8. Chris Hala’ufia
Replacements: 16. Brian Blaney; 17. Cai Griffiths; 18. Leo Halavatau; 19. George Skivington; 20. Ofisa Treviranus; 21. Steven Shingler; 22. Shane Geraghty; 23. Jack Moates