Auch lock Ilia Zedginidze leads the side and is one of only four survivors from the team which troubled Argentina before succumbing to a 33-3 defeat on Tuesday night.
Zedginidze continues his second-row partnership with Mamuka Gorgodze, the Montpellier forward who will be winning his 25th cap at the Stade Chaban-Delmas.
Massy's Giorgi Chkhaidze resumes his back row duties, although he has been switched from the blindside to number eight.
Pau fly-half Merab Kvirikashvili, who impressed against the Pumas, is the only threequarter to have retained his place in the team.
Georgia are being hampered by a fixture list that demands they face two of the world's top six teams within five days.
The Irish, who sit seven places higher in the world rankings, complete a gruelling programme that Cheishvili has confirmed shaped his team selection.
"The schedule is very uncomfortable for us and we didn't choose it," he said.
"But we have prepared for this by planning to use our squad as much as possible.
"It's difficult but there is nothing we can do about it, we have to face the challenge.
"We don't see it like the bigger teams get treated better than the smaller ones, it's just the way it."
Georgia: 15 Otar Barkalaia, 14 Giorgi Elizbarashvili, 13 Revaz Gigauri, 12 Davit Kacharava, 11 Giorgi Shkinin, 10 Merab Kvirikashvili, 9 Bidzina Samkharadze, 8 Giorgi Chkhaidze, 7 Rati Urushadze, 6 Ilia Maisuradze, 5 Mamuka Gorgodze, 4 Ilia Zedginidze, 3 Avtandil Kopaliani, 2 Goderdzi Shvelidze, 1 Mamuka Magrakvelidze,
Replacements: 16 Akvsenti Giorgadze, 17 David Khinchagashvili, 18 Levan Datunashvili, 19 Zviad Maisuradze, 20 Irakli Abuseridze, 21 Malkhaz Urjukashvili, 22 Otar Eloshvili.
Date: Saturday, September 15
Kick-off: 21:00 (20:00 BST, 19:00 GMT)
Venue: Stade Chaban-Delmas, Bordeaux
Referee: Wayne Barnes
Touch judges: Malcolm Changleng, Paul Marks
Television match official: Federico Cuesta
Assessor: Tappe Henning