Saracens take on fellow Aviva Premiership rivals Sale Sharks at the Salford City Stadium in the Anglo Welsh LV=Cup on Friday evening.
Lorenzo Romano, Kameli Ratuvou, Joel Tomkins and Mouritz Botha come into the Saracens starting line-up from the side that beat Leicester Tigers 38-21 in the opening clash of the tournament last weekend.
For prop Romano, it is a first start in a Saracens shirt while Ratuvou has returned from international duty with Fiji to make up the centre pairing with Tomkins.
On the bench, hooker Scott Spurling comes into the matchday 23 along with Jackson Wray and David Strettle.
Prop Rick Reeves and scrum half Ali Price, who are on loan from Bedford Blues, come on to the bench.
Meanwhile Sale Sharks have named former Wallaby Cameron Shepherd at fullback and former England winger Mark Cueto on the wing where Shepherd played last week.
There is a new front row as Tony Buckley replaces Vadim Cobilas and Andy Powell is dropped from the team and replaced by new captain for this week David Seymour.
Match : Sale Sharks vs Saracens
Date : Friday 16/11/2012
Venue : Salford City Stadium
Kick Off : 8.00pm
Live on: N/A
Referee: Llyr ApGeraint Roberts (RFU)
Sale Sharks: 15.Cameron Shepherd, 14.Charlie Amesbury, 13.Corne Uys, 12.Jordan Davies, 11.Mark Cueto, 10.Danny Cipriani, 9.Dwayne Peel, 1.Eifion Lewis-Roberts, 2.Joe Ward, 3.Tony Buckley, 4.Fraser McKenzie, 5.Kearnan Myall, 6.James Gaskell, 7. David Seymour (capt.), 8.Richie Vernon
Replacements: 16.Tommy Taylor, 17.Ross Harrison, 18.Vadim Cobilas, 19.Tom Holmes, 20.James Doyle, 21.Will Cliff, 22.Rob Miller, 23.Will Addison
Saracens: 15.Ben Ransom, 14.Duncan Taylor, 13.Joel Tomkins, 12.Kameli Ratuvou, 11.James Short, 10 Nils Mordt (capt.), 9.Ben Spencer, 1.Nick Auterac, 2.Jamie George, 3.Lorenzo Romano, 4. George Kruis, 5.Mouritz Botha, 6.Nick Fenton-Wells, 7.Andy Saull, 8.Jono Ross
Replacements: 16.Scott Spurling, 17.Rick Reeves, 18.Carlos Nieto, 19.Eoin Sheriff, 20.Jackson Wray, 21.Ali Price, 22.Sam Stanley, 23.David Strettle