The Springboks will play Premiership log leaders Saracens at Wembley Stadium on Tuesday, November 17 (kick-off 7.30pm) as part of their Outgoing Tour schedule.
The midweek fixture at the 94,000-seat stadium is in addition to Tests against France, Italy and Ireland and a tour opener against Leicester Tigers .
Tickets for the Wembley match have been attractively priced at £10 for adults and £5 for under-16s.
Andy Marinos, acting managing director of SA Rugby, said: "Many South Africans have been excited by Saracens' outstanding start to the season, and we look forward to playing our full part in what will be a great evening for our players and coaches, and also the large expatriate South African community in London and south-east England."
The South African squad will travel to London after playing France in Toulouse on Saturday November 14 and will then move on to Udine, where they play Italy on Saturday November 21.
"This is sure to be another fantastic occasion," said Saracens chairman Nigel Wray.
"The Springboks are the No.1 team in the world at the moment, and it will be tremendous honour and a privilege for us to welcome them at Wembley, our new home from home in north London."
Peter de Villiers, Springbok coach, said: "We have enjoyed a fantastic year so far, and this match - against an in-form club team at one of the great stadiums in the world - will certainly become yet another highlight in this memorable season.
"Overseas tours always provide us with an opportunity to expose our emerging young talents to the international game and this will be a fantastic platform through which to do that.
"We expect Saracens to be tough but also believe in the abilities of our squad."
Saracens are coached by former Stormers and Western Province coach Brendan Venter.
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